SUG1 [25D5]

GWB-868995

IgG

HeLa

Cytoplasmic

From ascitic fluid Storage

For WB: Use at a dilution of 1:1 000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. Target protein

Cytoplasmic Myeloma: NS1 Human SUG1 (also known as p45 Rpt6 and Cim3) is a component of the 19S regulatory subunit of the 26S proteosome complex. It is one of the AAA ATPas found in the 19S regulatory complex that is thought to participate in the unfolding of ubiquitinated proteins in an ATP-dependent manner. It has also been shown to directly interact with the nucleotide excision repair protein XPB.

One of the six subunits forming the core-TFIIH basal transcription factor. Interacts with PUF60.

Defects in ERCC3 are the cause of xeroderma pigmentosum complementation group B (XP-B) [MIM:610651]; also known as xeroderma pigmentosum II (XP2) or XP group B (XPB) or xeroderma pigmentosum group B combined with Cockayne syndrome (XP-B/CS). Xeroderma pigmentosum is an autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin high predisposition for developing cancers on areas exposed to sunlight and in some cases neurological abnormalities. Some XP-B patients present features of Cockayne syndrome including dwarfism sensorineural deafness microcephaly mental retardation pigmentary retinopathy ataxia decreased nerve conduction velocities.

Belongs to the helicase family. RAD25/XPB subfamily.

Contains 1 helicase C-terminal domain.