PPARA (peroxisome proliferator-activated receptor alpha)

GWB-557F75

1:12500

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. Peroxisome proliferators include hypolipidemic drugs. herbicides. leukotriene antagonists. and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants andSummary: Peroxisome proliferators include hypolipidemic drugs herbicides leukotriene antagonists and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors called PPARs which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha beta/delta and gamma) have been identified. This protein is the subtype PPAR-alpha which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene although the full-length nature of only two has been determined. Summary: Peroxisome proliferators include hypolipidemic drugs herbicides leukotriene antagonists and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors called PPARs which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha beta/delta and gamma) have been identified. This protein is the subtype PPAR-alpha which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene although the full-length nature of only two has been determined. [provided by RefSeq]. S. et al. . (2004) Gastroenterology 127 (5). 1436-1445.