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CFLAR (CASP8 and FADD-like apoptosis regulator)

CFLAR (CASP8 and FADD-like apoptosis regulator)

ArtNr	18-003-42865
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Antibodies Western Blot Cardiovascular Research Ischemia & Reperfusion Injury Primary Antibodies By Organ Colorectal Cancer
Typ	Antibody
Applikationen	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-F0708E
Similar products	18-003-42865
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Genway ID:	GWB-F0708E
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human CFLAR.
ELISA Titre:	1:312500
Category:	Tumor Suppressor Genes & Apoptosis
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. CFLAR might contribute to the carcinogenesis and aggressiveness of endometrial carcinoma and might be a useful prognostic factor in the tumor. CFLAR is specially overexpressed in colon cancers and it might contribute to carcinogenesis of normal colonic mu
Function:	Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
Subunit:	TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC) formed by TNFRSF6 FADD and caspase-8. A proteolytic fragment (p43) stays associated with the DISC. Also interacts with caspase-10 caspase-3 TRAF1 TRAF2 and Bcl-X(L) (in vitro). Interacts with HBV protein X.
Tissue Specificity:	Widely expressed. Higher expression in skeletal muscle pancreas heart kidney placenta and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
Induction:	Repressed by IL-2 after TCR stimulation during progression to the S-phase of the cell cycle.
Domain:	The caspase domain lacks the active sites residues involved in catalysis.
Ptm:	Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43 and p12.
Similarity:	Belongs to the peptidase C14 family [view classification].
Similarity:	Contains 2 DED (death effector) domains. Kondo. G. . et al. . (2005) Oncol Rep. 14(5). 1215-22.

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Menge: 0.1 mg

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Lieferung vsl. bis 11.09.2025

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