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CFLAR (CASP8 and FADD-like apoptosis regulator)

CFLAR (CASP8 and FADD-like apoptosis regulator)

Item no.	18-003-42865
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Antibodies Western Blot Cardiovascular Research Ischemia & Reperfusion Injury Primary Antibodies By Organ Colorectal Cancer
Type	Antibody
Applications	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-F0708E
Similar products	18-003-42865
Available
Genway ID:	GWB-F0708E
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human CFLAR.
ELISA Titre:	1:312500
Category:	Tumor Suppressor Genes & Apoptosis
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. CFLAR might contribute to the carcinogenesis and aggressiveness of endometrial carcinoma and might be a useful prognostic factor in the tumor. CFLAR is specially overexpressed in colon cancers and it might contribute to carcinogenesis of normal colonic mu
Function:	Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
Subunit:	TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC) formed by TNFRSF6 FADD and caspase-8. A proteolytic fragment (p43) stays associated with the DISC. Also interacts with caspase-10 caspase-3 TRAF1 TRAF2 and Bcl-X(L) (in vitro). Interacts with HBV protein X.
Tissue Specificity:	Widely expressed. Higher expression in skeletal muscle pancreas heart kidney placenta and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
Induction:	Repressed by IL-2 after TCR stimulation during progression to the S-phase of the cell cycle.
Domain:	The caspase domain lacks the active sites residues involved in catalysis.
Ptm:	Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43 and p12.
Similarity:	Belongs to the peptidase C14 family [view classification].
Similarity:	Contains 2 DED (death effector) domains. Kondo. G. . et al. . (2005) Oncol Rep. 14(5). 1215-22.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 9/11/2025

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