PTRF

ArtNr	18-003-43949
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Antibodies Western Blot Primary Antibodies By Organ Lung Cancer
Typ	Antibody
Applikationen	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-2A0638
Similar products	18-003-43949
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Genway ID:	GWB-2A0638
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Mouse Ptrf.
ELISA Titre:	1:312500
Category:	TF for Mouse
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. In mouse. pausing of elongation complexes is mediated by the transcription termination factor TTF-I bound to the `Sal box` terminator downstream of the rDNA transcription unit. PTRF is a Pol I and transcript release factor for dissociation of paused terna
Function:	Termination of transcription by RNA polymerase I involves pausing of transcription by TTF1 and the dissociation of the transcription complex releasing pre-rRNA and RNA polymerase I from the template. PTRF is required for dissociation of the ternary transcription complex.
Subunit:	Interacts with LIPE in the adipocyte cytoplasm (By similarity). Interacts with RNA polymerase I and TTF1. Binds the 3\' end of pre-rRNA. Interacts with transcription factor ZNF148.
Subcellular Location:	Cell membrane caveola (By similarity). Cell membrane (By similarity). Microsome (By similarity). Cytoplasm cytosol (By similarity). Mitochondrion (By similarity). Nucleus (By similarity). Note=Found at the surface of the caveolae. Also found in the plasma membrane microsomal and cytosolic fractions and at a low level in the mitochondrial and nuclear fractions (By similarity). Translocates to the cytoplasm from caveolae upon insulin stimulation (By similarity).
Tissue Specificity:	Expressed in all tissues tested (lung heart testis kidney muscle liver spleen and brain). Highest levels in lung and heart.
Ptm:	Phosphorylated. Present in active and inactive forms. Changes in phosphorylation pattern may alter activity.
Similarity:	Belongs to the PTRF/SDPR family. Miyoshi. K. . et al. . (2001) Genomics 71 (2). 150-155.

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Menge: 0.1 mg

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