Cyclin H

ArtNr	18-272-195135
Hersteller	GENWAY
Menge	0.05 ml
Kategorie	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Blastoma Carcinoma Cell Biology Cell Status Western Blot Proliferation Primary Antibodies By Organ Bladder Cancer
Typ	Antibody
Applikationen	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-1432E4
Similar products	18-272-195135
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Genway ID:	GWB-1432E4
Isotype:	IgG
Immunogen:	Recombinant full length protein (Human).
Antigen Species:	Human
Positive Control:	HeLa cell nuclear extract
Target:	Cyclin H
Localization:	Nuclear Storage
Preservative:	0. 014% Thimerosal / MerthiolateConstituents: 30% Glycerol
Application Note:	WB: Use at a dilution of 1/500. Detects a band of approximately 36 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Nuclear Cyclin H belongs to the highly conserved cyclin family whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin H forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases and thus functions as a CDK-activating kinase (CAK). Cyclin H and its kinase partner are components of TFIIH as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes suggesting an important link between basal transcription control and the cell cycle machinery.
Function:	Regulates CDK7 the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1 CDK2 CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A) allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Subunit:	Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
Subcellular Location:	Nucleus.
Similarity:	Belongs to the cyclin family. Cyclin C subfamily.

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