DNA polymerase delta

ArtNr	18-272-198039
Hersteller	GENWAY
Menge	0.05 ml
Kategorie	Oncology Antibodies Western Blot Primary Antibodies By Organ Bladder Cancer
Typ	Antibody
Applikationen	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-7399F1
Similar products	18-272-198039
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Genway ID:	GWB-7399F1
Isotype:	IgG
Immunogen:	Recombinant protein encoding amino acids 1-140 of the large subunit of human DNA polymerase d.
Antigen Species:	Human
Positive Control:	HeLa
Target:	DNA polymerase delta
Purification Note:	From polyclonal serum.
Application Note:	For WB: Use at a dilution of 1:500. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. Expression system: pQE-30 DNA polymerase d (delta) functions in DNA replication and DNA repair. It also possesses 3\' to 5\' exonuclease activity. In leading strand synthesis it requires the processivity factor PCNA. It is also possibly involved in the completion of DNA synthesis during Okazaki fragment elongation following the initiation of synthesis by the DNA polymerase a/primase complex
Function:	Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3\' - to 5\' -direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex.
Catalytic Activity:	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Subunit:	Heterotetramer composed of subunits of 125 kDa 50 kDa 66 kDa and 12 kDa. The 125 kDa subunit contains the polymerase active site and most likely the active site for the 3\' -5\' exonuclease activity. Interacts with WRNIP1. Interacts with POLD4 and PCNA.
Subcellular Location:	Nucleus.
Miscellaneous:	In eukaryotes there are five DNA polymerases: alpha beta gamma delta and epsilon which are responsible for different reactions of DNA synthesis.
Similarity:	Belongs to the DNA polymerase type-B family.

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