STAT6 phospho Y641+D9253

GWB-27BB44

Synthetic phospho-Tyr641 peptide corresponding to residues around Tyr641 of human Stat6 conjugated to KLH.

This product detects Stat6 only when phosphorylated at phosphotyrosine 641.

STAT6

This antibody is affinity-purified using the protein A and peptide affinity chromatography. Storage

WB: Use at a dilution of 1/1000 this is recommended using an extract from interleukin-4-treated Daudi cells. Predicted

Nuclear; translocated into the nucleus in response to phosphorylation. Stat 6 protein is a transcription factor activated by cytokines particularly interleukin 4 and IL 13. (Stat6-/-) were found to be deficient in IL 4 mediated functions including Th2 helper T cell differentiation expression of cell surface markers T cell proliferation immunoglobulin class switching to IgE and partial loss of IL 4 mediated proliferation. Stat 6 mRNA has been detected in peripheral bloodlymphocytes colon intestine ovary prostate thymus spleen kidney liver lung and placenta. Stat 6 is critically involved in Th2 immune response.

signal transduction and activation of transcription. Involved in interleukin-4 signalling.

Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.

Belongs to the transcription factor STAT family.