Claudin 4

ArtNr	18-272-196247
Hersteller	GENWAY
Menge	0.5 ml
Kategorie	Oncology Antibodies Immunohistochemistry Primary Antibodies By Organ Uterine, Ovarian & Cervical Cancer
Typ	Antibody
Applikationen	IHC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-2FC968
Similar products	18-272-196247
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Genway ID:	GWB-2FC968
Isotype:	IgG
Immunogen:	Synthetic peptide (Human) (C terminal).
Antigen Species:	Human
Positive Control:	Tonsil and ovarian carcinoma cells
Target:	Claudin 4
Concentration:	Lot specific and is stated on the vial Storage
Buffer:	Phosphate-buffered saline pH 7. 4 containing 1% BSA and 0. 09% sodium azide
Application Note:	IHC-P: Use at a dilution of 1/200. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer pH 6. 0 for 10 min followed by cooling at RT for 20 min. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Cell Membrane Claudin 1-8 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact; made up of network of strands to act as a molecular gasket for preventing the leakage of ions water etc. between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition.
Function:	Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity).
Subunit:	Directly interacts with TJP1/ZO-1 TJP2/ZO-2 and TJP3/ZO-3 (By similarity).
Subcellular Location:	Cell junction tight junction (By similarity). Cell membrane; Multi-pass membrane protein (By similarity).
Disease:	Haploinsufficiency of CLDN4 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11. 23.
Similarity:	Belongs to the claudin family.

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