« Back
Home /
Claudin 4

Claudin 4

Item no.	18-272-196247
Manufacturer	GENWAY
Amount	0.5 ml
Category	Oncology Antibodies Immunohistochemistry Primary Antibodies By Organ Uterine, Ovarian & Cervical Cancer
Type	Antibody
Applications	IHC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-2FC968
Similar products	18-272-196247
Available
Genway ID:	GWB-2FC968
Isotype:	IgG
Immunogen:	Synthetic peptide (Human) (C terminal).
Antigen Species:	Human
Positive Control:	Tonsil and ovarian carcinoma cells
Target:	Claudin 4
Concentration:	Lot specific and is stated on the vial Storage
Buffer:	Phosphate-buffered saline pH 7. 4 containing 1% BSA and 0. 09% sodium azide
Application Note:	IHC-P: Use at a dilution of 1/200. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer pH 6. 0 for 10 min followed by cooling at RT for 20 min. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Cell Membrane Claudin 1-8 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact; made up of network of strands to act as a molecular gasket for preventing the leakage of ions water etc. between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition.
Function:	Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity).
Subunit:	Directly interacts with TJP1/ZO-1 TJP2/ZO-2 and TJP3/ZO-3 (By similarity).
Subcellular Location:	Cell junction tight junction (By similarity). Cell membrane; Multi-pass membrane protein (By similarity).
Disease:	Haploinsufficiency of CLDN4 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11. 23.
Similarity:	Belongs to the claudin family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 0.5 ml

available

Delivery expected until 10/30/2025

Express Delivery: Save 2 days

Compare

Add to wishlist

Get an offer