Claudin 5

ArtNr	18-272-196249
Hersteller	GENWAY
Menge	0.5 ml
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Development Antibodies Immunohistochemistry Western Blot Primary Antibodies By Organ Lung Cancer
Typ	Antibody
Applikationen	WB, IHC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-50A54B
Similar products	18-272-196249
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Genway ID:	GWB-50A54B
Isotype:	IgG
Immunogen:	Synthetic peptide (unfortunately the amino acid sequence is considered to be commercially sensitive) (Mouse) (C terminal).
Positive Control:	Lung
Target:	Claudin 5
Concentration:	Lot specific Storage
Buffer:	Phosphate-buffered saline pH 7. 4 containing 1% BSA and 0. 09% sodium azide
Application Note:	IHC-P: Use at a dilution of 1/50 for 10 minutes at room temperature. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer pH 6. 0 for 10 minutes followed by cooling at room temperature for 20 min. WB: Use at an assay dependent dilution. Predicted
Molecular Weight:	24 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Cell Membrane Claudin 1-8 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact; made up of network of strands to act as a molecular gasket for preventing the leakage of ions water etc. between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition.
Function:	Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity).
Subunit:	Directly interacts with TJP1/ZO-1 TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ (By similarity).
Subcellular Location:	Cell junction tight junction. Cell membrane; Multi-pass membrane protein.
Similarity:	Belongs to the claudin family.

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