SARS E protein

IgG

Reacts with the C-terminal of the E protein of SARS-associated coronavirus.

Cell Membrane

0. 02% Sodium Azide. Constituents: PBS

Cell Membrane A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive stranded RNA approximately 27 to 31kb in length. SARS infection can be mediated by the binding of the viral spike protein a glycosylated 139 kDa protein and the major surface antigen of the virus to the angiotensin converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2. The evelope protein is a component of the viral envelope that plays a central role in virus morphogenesis and assembly. It may be sufficient to form virus like particles.

Homooligomer. Interacts with the M membrane protein in the budding compartment of the host cell which is located between endoplasmic reticulum and the Golgi complex (By similarity). Interacts with the accessory proteins 3a and 7a.

Belongs to the coronaviruses E protein family.