Beta-2 Adrenoceptor

Synthetic peptide - KLH conjugated. Epitope: 5th transmembrane domain of human

Adrenergic Uses: Immunohistochemistry - Paraffin (IHC-P) (3-5 & #956; g/ml). The beta-2 adrenoceptor (ADRB2) is an Adrenergic Receptor expressed in smooth muscle and metabolic tissues. Activation of this receptor induces a decrease in gastrointestinal motility bronchodilation vasodilation in skeletal and cardiac muscle and glycogenolysis in liver. The beta-2 adrenoceptor is also a major lipolytic receptor in human fat cells and may be involved in obesity. Agonists of ADRB2 are most widely used for the treatment of asthma. In complex with beta-arrestin-1 and c-src the beta-2 adrenergic receptor activates MAP kinases ERK1(MAPK3) and ERK2 (MAPK1).

Binds SLC9A3R1 and GPRASP1.

Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation.

Polymorphic forms of ADRB2 could impart some form of nocturnal asthma.