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Beta-2 Adrenoceptor

Beta-2 Adrenoceptor

Item no.	18-461-10853
Manufacturer	GENWAY
Amount	0.05 ml
Category	Oncology Metabolism Diabetes Glucose Homeostasis Antibodies Obesity Immunohistochemistry Cardiovascular Research Heart Failure Myocardial Infarction Hypertension Primary Antibodies Arrhythmias By Organ Skin Cancer
Type	Antibody
Applications	IHC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-F42A39
Similar products	18-461-10853
Available
Genway ID:	GWB-F42A39
Immunogen:	Synthetic peptide - KLH conjugated. Epitope: 5th transmembrane domain of human
Target:	Frizzled-3 (FZD3)Family: GPCR
Subfamily:	Adrenergic Uses: Immunohistochemistry - Paraffin (IHC-P) (3-5 & #956; g/ml). The beta-2 adrenoceptor (ADRB2) is an Adrenergic Receptor expressed in smooth muscle and metabolic tissues. Activation of this receptor induces a decrease in gastrointestinal motility bronchodilation vasodilation in skeletal and cardiac muscle and glycogenolysis in liver. The beta-2 adrenoceptor is also a major lipolytic receptor in human fat cells and may be involved in obesity. Agonists of ADRB2 are most widely used for the treatment of asthma. In complex with beta-arrestin-1 and c-src the beta-2 adrenergic receptor activates MAP kinases ERK1(MAPK3) and ERK2 (MAPK1).
Function:	Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Subunit:	Binds SLC9A3R1 and GPRASP1.
Subcellular Location:	Cell membrane; Multi-pass membrane protein.
Ptm:	Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation.
Ptm:	Phosphorylated by PKA and BARK upon agonist stimulation which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK. Phosphorylated upon DNA damage probably by ATM or ATR.
Disease:	Polymorphic forms of ADRB2 could impart some form of nocturnal asthma.
Similarity:	Belongs to the G-protein coupled receptor 1 family [view classification].

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.05 ml

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