RABBIT ANTI BRSK1

GWB-E0439F

Polyclonal IgGSpecies Cross Reactivity: Reacts with: Mouse RatN. B. Antibody reactivity and working conditions may vary between species.

Recognises human BR serine-threonine kinase 1 (BRSK1) a cytoplasmic and nuclear protein belonging to the protein kinase super family. BRSK1 is a widely expressed protein with highest levels being detected in the brain and testis. It is essential for the polarization forebrain neurones which results in the distinct properties of axons and dendrites. Research suggests that BRSK1 is involved in the regulation of G2/M arrest and functions as a checkpoint kinase following UV- or methyl methane sulfonate (but not IR-) induced DNA damage. BRSK1 phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo. Multiple isoforms of BRSK1 have been identified. Recommended Secondary Antibodies: Sheep Anti Rabbit IgG

Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage. Ref. 3Tissue specificityWidely expressed with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle. Ref. 3Sequence similaritiesBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily. Contains 1 protein kinase domain. Contains 1 UBA domain. Sequence cautionThe sequence AAH16681. 1 differs from that shown. Reason: Erroneous initiation. 1. Cobbold S. & Metcalfe S. (1994) Monoclonal antibodies that define canine homologues of human CD antigens: summary of the First International Canine Leukocyte Antigen Workshop (CLAW). Tissue Antigens 43(3): 137-154. 2. Reis A. B. et al (2006) Phenotypic features of circulating leucocytes as immunological markers for clinical status and bone marrow parasite density in dogs naturally infected by Leishmania chagasi. Clin Exp Immunol. 146: 303-11.