PHOSPHODIESTERASE 2A


ArtNr	18-783-75530
Hersteller	GENWAY
Menge	0.05 mg
Kategorie	Oncology Antibodies Immunohistochemistry Cardiovascular Research Thrombosis & Hemostasis Primary Antibodies By Organ Brain Cancer
Typ	Antibody
Applikationen	IHC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-B69039
Similar products	18-783-75530
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Genway ID:	GWB-B69039
Specificity:	PHOSPHODIESTERASE 2A NCBI
Gene ID:	5138
Specificity:	PHOSPHODIESTERASE 2A
Immunogen:	Synthetic peptide: N-terminal region of human phosphodiesterase 2A conjugated to KLH.
Specificity Note:	This product detects an epitope within the N-terminal (NT) region of phosphodiesterase 2A (PDE2A) a 100kD cyclic nucleotide phosphodiesterase (PDE). Three isoforms of PDE2A have been reported (PDE2A1 PDE2A2 and PDE2A3) which arise from a single gene by alternative splicing events. PDE2A can degrade both cAMP and cGMP but degrades cGMP with greater efficacy. PDE2A is expressed in a variety of tissue types with greatest expression in the brain where it is localised in the cerebellum and neocortex. PDE2A has been implicated in penile erectile dysfunction and in the regulation of fluid and inflammatory cell transport across the endothelial cell barrier.
Immunohistology:	This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6. 0 is recommended for this purpose. Histology: Kidney
Antiserum Preparation:	Antisera to phosphodiesterase 2A (NT) were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution:	Phosphate buffered saline pH7. 7
Preservative Stabilisers:		0. 09% Sodium Azide (NaN3) Suggested
Dilution:	Suggested
Dilution:	Immunohistology - Paraffin - 15 - 25ug/ml
Function:	Hydrolyzes both cyclic AMP (cAMP) and cyclic GMP (cGMP).
Catalytic Activity:	Nucleoside 3\' 5\' -cyclic phosphate + H2O = nucleoside 5\' -phosphate.
Subunit:	Homodimer (By similarity).
Subcellular Location:	Membrane; Peripheral membrane protein (Potential).
Tissue Specificity:	Expressed in brain and to a lesser extent in heart placenta lung skeletal muscle kidney and pancreas.
Similarity:	Belongs to the cyclic nucleotide phosphodiesterase family.
Similarity:	Contains 2 GAF domains. 1. Sadhu. K. et al. (1999) Differential Expression of the Cyclic GMP-stimulated Phosphodiesterase PDE2A in Human Venous and Capillary Endothelial Cells.

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