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PHOSPHODIESTERASE 2A

PHOSPHODIESTERASE 2A


Item no.	18-783-75530
Manufacturer	GENWAY
Amount	0.05 mg
Category	Oncology Antibodies Immunohistochemistry Cardiovascular Research Thrombosis & Hemostasis Primary Antibodies By Organ Brain Cancer
Type	Antibody
Applications	IHC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-B69039
Similar products	18-783-75530
Available
Genway ID:	GWB-B69039
Specificity:	PHOSPHODIESTERASE 2A NCBI
Gene ID:	5138
Specificity:	PHOSPHODIESTERASE 2A
Immunogen:	Synthetic peptide: N-terminal region of human phosphodiesterase 2A conjugated to KLH.
Specificity Note:	This product detects an epitope within the N-terminal (NT) region of phosphodiesterase 2A (PDE2A) a 100kD cyclic nucleotide phosphodiesterase (PDE). Three isoforms of PDE2A have been reported (PDE2A1 PDE2A2 and PDE2A3) which arise from a single gene by alternative splicing events. PDE2A can degrade both cAMP and cGMP but degrades cGMP with greater efficacy. PDE2A is expressed in a variety of tissue types with greatest expression in the brain where it is localised in the cerebellum and neocortex. PDE2A has been implicated in penile erectile dysfunction and in the regulation of fluid and inflammatory cell transport across the endothelial cell barrier.
Immunohistology:	This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6. 0 is recommended for this purpose. Histology: Kidney
Antiserum Preparation:	Antisera to phosphodiesterase 2A (NT) were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution:	Phosphate buffered saline pH7. 7
Preservative Stabilisers:		0. 09% Sodium Azide (NaN3) Suggested
Dilution:	Suggested
Dilution:	Immunohistology - Paraffin - 15 - 25ug/ml
Function:	Hydrolyzes both cyclic AMP (cAMP) and cyclic GMP (cGMP).
Catalytic Activity:	Nucleoside 3\' 5\' -cyclic phosphate + H2O = nucleoside 5\' -phosphate.
Subunit:	Homodimer (By similarity).
Subcellular Location:	Membrane; Peripheral membrane protein (Potential).
Tissue Specificity:	Expressed in brain and to a lesser extent in heart placenta lung skeletal muscle kidney and pancreas.
Similarity:	Belongs to the cyclic nucleotide phosphodiesterase family.
Similarity:	Contains 2 GAF domains. 1. Sadhu. K. et al. (1999) Differential Expression of the Cyclic GMP-stimulated Phosphodiesterase PDE2A in Human Venous and Capillary Endothelial Cells.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.05 mg

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Delivery expected until 9/11/2025

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