VITRONECTIN


ArtNr	18-783-76262
Hersteller	GENWAY
Menge	1 ml
Kategorie	Oncology Neuroscience Neural Adhesion Molecules Infectious Diseases Viral Infections Coronavirus (COVID-19) Antibodies Cell Biology Cell Stainings ECM Primary Antibodies By Organ Pancreatic Cancer
Typ	Antibody
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-B38B98
Similar products	18-783-76262
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Genway ID:	GWB-B38B98
Specificity:	VITRONECTINNCBI
Gene ID:	7448
Specificity:	VITRONECTIN
Immunogen:	Human vitronectin purified from plasma
Specificity Note:	This product recognises human vitronectin a plasma protein of 78-83kD which may exist in either monomeric or dimeric forms. Vitronectin is a multifunctional protein being a complement lysis inhibitor and also a scavenger protein for macromolecular products of the complement and homeostasis cascades.
Antiserum Preparation:	Antisera to human vitronectin were raised by repeated immunisation of sheep with highly purified antigen. Purified IgG prepared by ion exchange chromatography.
Buffer Solution:	Glycine buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium Azide0. 1%EACA0. 01%Benzamidine1mMEDTASuggested
Dilution:	Suggested
Dilution:	Immunodiffusion - Neat
Function:	Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Function:	Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
Subunit:	Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1 and insulin.
Subcellular Location:	Secreted extracellular space.
Tissue Specificity:	Plasma.
Domain:	The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.
Ptm:	Sulfated on 2 tyrosine residues.
Ptm:	N- and O-glycosylated (By similarity).
Ptm:	Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.
Ptm:	It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
Similarity:	Contains 4 hemopexin-like domains.
Similarity:	Contains 1 SMB (somatomedin-B) domain.

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Lieferung vsl. bis 11.09.2025

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