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VITRONECTIN

VITRONECTIN


Item no.	18-783-76262
Manufacturer	GENWAY
Amount	1 ml
Category	Oncology Neuroscience Neural Adhesion Molecules Infectious Diseases Viral Infections Coronavirus (COVID-19) Antibodies Cell Biology Cell Stainings ECM Primary Antibodies By Organ Pancreatic Cancer
Type	Antibody
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-B38B98
Similar products	18-783-76262
Available
Genway ID:	GWB-B38B98
Specificity:	VITRONECTINNCBI
Gene ID:	7448
Specificity:	VITRONECTIN
Immunogen:	Human vitronectin purified from plasma
Specificity Note:	This product recognises human vitronectin a plasma protein of 78-83kD which may exist in either monomeric or dimeric forms. Vitronectin is a multifunctional protein being a complement lysis inhibitor and also a scavenger protein for macromolecular products of the complement and homeostasis cascades.
Antiserum Preparation:	Antisera to human vitronectin were raised by repeated immunisation of sheep with highly purified antigen. Purified IgG prepared by ion exchange chromatography.
Buffer Solution:	Glycine buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium Azide0. 1%EACA0. 01%Benzamidine1mMEDTASuggested
Dilution:	Suggested
Dilution:	Immunodiffusion - Neat
Function:	Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Function:	Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
Subunit:	Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1 and insulin.
Subcellular Location:	Secreted extracellular space.
Tissue Specificity:	Plasma.
Domain:	The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.
Ptm:	Sulfated on 2 tyrosine residues.
Ptm:	N- and O-glycosylated (By similarity).
Ptm:	Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.
Ptm:	It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
Similarity:	Contains 4 hemopexin-like domains.
Similarity:	Contains 1 SMB (somatomedin-B) domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 ml

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Delivery expected until 9/11/2025

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