CSK


ArtNr	18-783-76553
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Antibodies Immunohistochemistry Western Blot ELISA Primary Antibodies By Organ Lung Cancer
Typ	Antibody
Applikationen	WB, IHC, ELISA
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-5AF841
Similar products	18-783-76553
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Genway ID:	GWB-5AF841
Specificity:	CSK NCBI
Gene ID:	1445
Specificity:	CSK
Immunogen:	Peptide sequence EQLEHIKTHELHL corresponding to the C-terminal region of CSK (NP_004374. 1).
Specificity Note:	This product specifically recognises an epitope within the C-terminal (CT) region of CSK (c-src tyrosine kinase) a cytoplasmic tyrosine kinase ubiquitously expressed as two mRNA species which down-regulates the activity of the c-src oncoprotein.
Immunohistology:	This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. TRIS/EDTA buffer pH 9. 0 is recommended for this purpose. Histology: Human Tonsil
Antiserum Preparation:	Antisera to human CSK (CT) were raised by repeated immunisations of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Buffer Solution:	TRIS buffered saline pH7. 3
Preservative Stabilisers:		0. 02%Sodium Azide0. 5%Bovine Serum AlbuminSuggested
Dilution:	Western Blot: This product detects a band of approximately 50kDa in Jurkat cell lysates. Suggested
Dilution:	Immunohistology - Paraffin - 0. 1ug/ml - 0. 3ug/mlmmunohistology - Resin - & gt; 1/32 000Western Blotting - 0. 5ug/ml - 2. 0ug/ml
Function:	Specifically phosphorylates \' Tyr-504\' on LCK which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.
Catalytic Activity:	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit:	Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1 PAG1 LIME1 and TGFB1I1.
Subcellular Location:	Cytoplasm (By similarity). Cell membrane (By similarity). Note=Mainly cytoplasmic also present in lipid rafts (By similarity).
Tissue Specificity:	Expressed in lung and macrophages.
Ptm:	Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.
Similarity:	Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
Similarity:	Contains 1 protein kinase domain.
Similarity:	Contains 1 SH2 domain.
Similarity:	Contains 1 SH3 domain.

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Menge: 0.1 mg

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Lieferung vsl. bis 11.09.2025

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