Endo G (C-term)

GWB-B44398

A synthetic peptide corresponding to residues on the C-terminus of human Endo G was used as an immunogen.

WB: 1:2000 - 5000. Endonuclease G (endoG) is a mitochondrion-specific nuclease that translocates to the nucleus during apoptosis. Once released from mitochondria endoG cleaves chromatin DNA into nucleosomal fragments independently of caspases. Therefore endoG represents a caspase-independent apoptotic pathway initiated from the mitochondria (1). Endonuclease G (EndoG) is a nuclear-encoded mitochondrial protein reported to be important for both nuclear DNA fragmentation during apoptosis and mitochondrial DNA replication. Findings indicate that EndoG is essential during early embryogenesis and plays a critical role in normal apoptosis and nuclear DNA fragmentation (2). 1. Li LY et al. Nature 412(6842):95-9 20012. Zhang J et al. Proc Natl Acad Sci 100(26):15782-7 2003. 3. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487