Cytokeratin 7 (C-term)

GWB-32500E

A synthetic peptide corresponding to residues near the C-terminus of human CK-7 was used as an immunogen.

WB: 1:1 000 - 10 000ICC: 1:250 - 500FC: 1:20IP: 1:50. Cytokeratins are cytoplasmic intermediate filament proteins expressed by epithelial cells. Keratin 7 (CK7) is expressed in a wide range of epithelial structures in humans. The expression pattern in mice is similar to the reported human distribution with substantial expression observed in lung bladder mesothelium hair follicle and ductal structures (1). Protein expression levels of CK7 appear significantly higher in chromophobe RCC compared to oncocytoma (p < 0. 001). Studies provide further evidence that CK7 and parvalbumin immunostains may be useful in differentiating oncocytoma from chromophobe RCC in problematic cases (2). Also the pattern of immunohistochemical expression of CK 7 along with CK 20 is commonly used to assess possible primary sites of metastatic carcinomas (3). 1. Smith FJ et al. Biochem Biophys Res Commun. 297(4):818-27 2002. 2. Adley BP et al. Anal Quant Cytol Histol 28(4):228-36 20063. Coons SW et al. Endocr Pathol 16(3):201-10 2005. 4. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487