« Zurück
Startseite /
Plakophilin 1 [3G250]

Plakophilin 1 [3G250]

ArtNr	20-272-191119
Hersteller	GENWAY
Menge	0.05 mg
Kategorie	Oncology Antibodies Immunoprecipitation Western Blot ELISA Immunofluorescence Primary Antibodies By Organ Skin Cancer
Typ	Antibody
Applikationen	WB, IF, IP, ELISA
Clon	3G250
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-9829E9
Similar products	20-272-191119
Lieferbar
Genway ID:	GWB-9829E9
Clone:	3G250
Isotype:	IgG1
Immunogen:	Plakophilin 1 (Human) (N terminal).
Antigen Species:	Human
Specificity:	Reacts with the N-terminus of human plakophilin 1.
Positive Control:	MCF-7 cell lysates
Target:	Plakophilin 1
Localization:	Nuclear
Concentration:	0. 5 mg/ml Storage
Preservative:	0. 1% Sodium Azide; Constituents: PBS. pH 7. 2
Application Note:	ELISA: Use at a dilution of 1/100 - 1/1000. IF: Use at a concentration of 3 - 10 µ g/ml. IP: Use 2µ g per IP reaction. WB: Use at a concentration of 1 - 3 µ g/ml. Predicted
Molecular Weight:	87 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Nuclear Plays a role in formation of desmosomal plaques and is found in desmosomes of most simple and stratified epithelia. Not found in cell types that have non-epithelial desmosomes. Absent in fibroblasts and other connective tissue types including sarcomas.
Function:	Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis.
Subcellular Location:	Isoform 1: Nucleus. Cell junction desmosome.
Subcellular Location:	Nucleus.
Tissue Specificity:	Nuclear isoform is widely expressed. Isoform 1 is expressed in stratified squamous complex glandular duct and bladder epithelia.
Disease:	Defects in PKP1 are the cause of ectodermal dysplasia/skin fragility syndrome (EDSFS) [MIM:604536]; also known as McGrath syndrome. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSFS is characterized by features of both cutaneous fragility and congenital ectodermal dysplasia affecting skin hair and nails. There is no evidence of significant abnormalities in other epithelia or tissues. Desmosomes in the skin are small and poorly formed with widening of keratinocyte intercellular spaces and perturbed desmosome/keratin intermediate filament interactions.
Similarity:	Belongs to the beta-catenin family.
Similarity:	Contains 9 ARM repeats.

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

Produkt-Datenblatt anfordern

Sicherheitsdatenblatt anfordern

Einfache Bestellung Periodische Bestellung

Menge: 0.05 mg

lieferbar

Lieferung vsl. bis 09.10.2025

Express-Lieferung: 8 Tage sparen

Vergleichen

Auf den Wunschzettel

Angebot anfordern