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Plakophilin 1 [3G250]

Plakophilin 1 [3G250]

Item no.	20-272-191119
Manufacturer	GENWAY
Amount	0.05 mg
Category	Oncology Antibodies Immunoprecipitation Western Blot ELISA Immunofluorescence Primary Antibodies By Organ Skin Cancer
Type	Antibody
Applications	WB, IF, IP, ELISA
Clone	3G250
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-9829E9
Similar products	20-272-191119
Available
Genway ID:	GWB-9829E9
Clone:	3G250
Isotype:	IgG1
Immunogen:	Plakophilin 1 (Human) (N terminal).
Antigen Species:	Human
Specificity:	Reacts with the N-terminus of human plakophilin 1.
Positive Control:	MCF-7 cell lysates
Target:	Plakophilin 1
Localization:	Nuclear
Concentration:	0. 5 mg/ml Storage
Preservative:	0. 1% Sodium Azide; Constituents: PBS. pH 7. 2
Application Note:	ELISA: Use at a dilution of 1/100 - 1/1000. IF: Use at a concentration of 3 - 10 µ g/ml. IP: Use 2µ g per IP reaction. WB: Use at a concentration of 1 - 3 µ g/ml. Predicted
Molecular Weight:	87 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Nuclear Plays a role in formation of desmosomal plaques and is found in desmosomes of most simple and stratified epithelia. Not found in cell types that have non-epithelial desmosomes. Absent in fibroblasts and other connective tissue types including sarcomas.
Function:	Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis.
Subcellular Location:	Isoform 1: Nucleus. Cell junction desmosome.
Subcellular Location:	Nucleus.
Tissue Specificity:	Nuclear isoform is widely expressed. Isoform 1 is expressed in stratified squamous complex glandular duct and bladder epithelia.
Disease:	Defects in PKP1 are the cause of ectodermal dysplasia/skin fragility syndrome (EDSFS) [MIM:604536]; also known as McGrath syndrome. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSFS is characterized by features of both cutaneous fragility and congenital ectodermal dysplasia affecting skin hair and nails. There is no evidence of significant abnormalities in other epithelia or tissues. Desmosomes in the skin are small and poorly formed with widening of keratinocyte intercellular spaces and perturbed desmosome/keratin intermediate filament interactions.
Similarity:	Belongs to the beta-catenin family.
Similarity:	Contains 9 ARM repeats.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.05 mg

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Delivery expected until 10/9/2025

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