Insulin [8E2]

8E2

Full length native protein (purified).

No cross-reaction with free C-peptide.

SecretedConcentation: Lot specific Storage

ELISA: Use at an assay dependent dilution. Can be used as a detection antibody in an ELISA pair with 20-272-192288 (capture). Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate protein and lipid metabolism. Insulin enhances membrane transport of glucose amino acids and certain ions. It also promotes glycogen storage formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B or b-cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730]. Pharmaceutical: Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53.