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160kDa Neurofilament medium [NF-09]

160kDa Neurofilament medium [NF-09]

ArtNr	20-272-192729
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Targets for Rodent Neurosciences Antibodies Immunohistochemistry Western Blot ELISA Immunocytochemistry Primary Antibodies Schwann Cell Markers
Typ	Antibody
Applikationen	WB, IHC, ICC, ELISA
Clon	NF-09
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-5E2F31
Similar products	20-272-192729
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Genway ID:	GWB-5E2F31
Clone:	NF-09
Isotype:	IgG2a
Immunogen:	Pellet of pig brain cold stable proteins after depolymerization of microtubules.
Antigen Species:	Pig
Specificity:	This antibody reacts with both phosphorylated and non-phosphorylated forms of medium neurofilament protein (160 kDa) of various species.
Target:	160kDa Neurofilament medium
Concentration:	1 mg/ml
Purification Note:	Purified from ascites using protein A affinity chromatography. > 95 % (by PAGE). Storage
Buffer:	Phosphate buffered saline pH 7. 4 containing 15mM sodium azide
Application Note:	ELISA: Use at an assay dependant dilution. ICC: Use at an assay dependant dilution. IHC-P: Use at an assay dependant dilution. IHC-Fr: Use at an assay dependant dilution. WB: Use at a dilution of 1/1000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons and are composed predominantly of three major proteins called NF-L NF-M and NF-H.
Function:	Neurofilaments usually contain three intermediate filament proteins: L M and H which are involved in the maintenance of neuronal caliber.
Ptm:	There are a number of repeats of the tripeptide K-S-P NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.
Ptm:	Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H) the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function.
Similarity:	Belongs to the intermediate filament family.

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Menge: 0.1 mg

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