CD4 [LT4]

ArtNr	20-272-192899
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Antibodies Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody
Clon	LT4
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-792879
Similar products	20-272-192899
Lieferbar
Genway ID:	GWB-792879
Clone:	LT4
Isotype:	IgG1
Immunogen:	Normal human blood lymphocytes
Antigen Species:	Human
Specificity:	This antibody reacts with CD4 antigen (MW 59 kDa).
Target:	CD4
Localization:	Cell Membrane
Purification Note:	DEAE-column. Storage
Preservative:	0. 1% Sodium Azide; Constituents: PBS. pH 7. 4
Application Note:	IA: Use at a dilution of 1/4000. This antibody can be used to enumerate T helper / inducer subset in peripheral blood and tissue. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Cell Membrane Myeloma: x63-Ag8. 653 CD4 is present on 39+5% of normal peripheral blood lymphocytes and 90% of thymocytes. This antigen is found on the T helper cells. The CD4 molecule is the receptor for HIV.
Function:	Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Subunit:	Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins.
Subcellular Location:	Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with and sequesters CD4 in the endoplasmic reticulum.
Ptm:	Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Miscellaneous:	Primary receptor for HIV-1.
Similarity:	Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Similarity:	Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

Produkt-Datenblatt anfordern

Sicherheitsdatenblatt anfordern

Einfache Bestellung Periodische Bestellung

Menge: 0.1 mg

lieferbar

Lieferung vsl. bis 30.10.2025

Express-Lieferung: 1 Tage sparen

Vergleichen

Auf den Wunschzettel

Angebot anfordern