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CD4 [LT4]

CD4 [LT4]

Item no.	20-272-192899
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Antibodies Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Clone	LT4
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-792879
Similar products	20-272-192899
Available
Genway ID:	GWB-792879
Clone:	LT4
Isotype:	IgG1
Immunogen:	Normal human blood lymphocytes
Antigen Species:	Human
Specificity:	This antibody reacts with CD4 antigen (MW 59 kDa).
Target:	CD4
Localization:	Cell Membrane
Purification Note:	DEAE-column. Storage
Preservative:	0. 1% Sodium Azide; Constituents: PBS. pH 7. 4
Application Note:	IA: Use at a dilution of 1/4000. This antibody can be used to enumerate T helper / inducer subset in peripheral blood and tissue. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Cell Membrane Myeloma: x63-Ag8. 653 CD4 is present on 39+5% of normal peripheral blood lymphocytes and 90% of thymocytes. This antigen is found on the T helper cells. The CD4 molecule is the receptor for HIV.
Function:	Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Subunit:	Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins.
Subcellular Location:	Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with and sequesters CD4 in the endoplasmic reticulum.
Ptm:	Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Miscellaneous:	Primary receptor for HIV-1.
Similarity:	Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Similarity:	Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 10/30/2025

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