p37 [1320]

ArtNr	20-272-193360
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Antibodies Western Blot Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody
Applikationen	WB
Clon	1320
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-E21018
Similar products	20-272-193360
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Genway ID:	GWB-E21018
Clone:	1320
Isotype:	IgG
Immunogen:	Recombinant protein encoding the full-length p37 subunit ofhuman RFC purified from E. coli.
Positive Control:	HepG2 LNCAP MCF7 SKOV3
Target:	p37
Localization:	Nuclear
Concentration:	1 mg/ml
Purification Note:	From ascitic fluid Storage
Buffer:	Phosphate-buffered saline pH 7. 4 containing no preservatives
Application Note:	For WB: Use at a dilution of 1:1 000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researhcer. Target protein
Molecular Weight:	37 Myeloma: NS1 Human Replication Factor C (RFC) is a hetero-pentameric protein consisting of the p140 p40 p38 p37 and p36 subunits. RFC functions in the loading of the DNA polymerase delta processivity factor (PCNA Proliferating Cell nuclear Antigen) onto a primed DNA template during DNA synthesis and repair. RFC may also participate in the DNA damage checkpoint response with a PCNA-like hetero-trimer consisting of Hus 1 Rad 1 and Rad 9.
Function:	This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase\' s processibility during elongation of the leading strand.
Subunit:	Homotrimer. Interacts with KCTD10. Interacts with PPP1R15A (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with POLH POLK DNMT1 ERCC5/XPG FEN1 CDC6 APEX2 and POLDIP2. Interacts with EXO1 and SHPRH. Forms a ternary complex with DNTTIP2 and core histone. Interacts with POLD1 POLD3 and POLD4.
Subcellular Location:	Nucleus.
Ptm:	Upon methyl methanesulfonate-induced DNA damage mono-ubiquitinated by the UBE2B-RAD18 complex on Lys-164. This induces non-canonical poly-ubiquitination on Lys-164 through \' Lys-63\' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligase SHPRH whih is required for DNA repair.
Disease:	Antibodies are present in sera from patients with systemic lupus erythematosus.
Similarity:	Belongs to the PCNA family.

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