p37 [1320]

Item no.	20-272-193360
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Antibodies Western Blot Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Applications	WB
Clone	1320
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-E21018
Similar products	20-272-193360
Available
Genway ID:	GWB-E21018
Clone:	1320
Isotype:	IgG
Immunogen:	Recombinant protein encoding the full-length p37 subunit ofhuman RFC purified from E. coli.
Positive Control:	HepG2 LNCAP MCF7 SKOV3
Target:	p37
Localization:	Nuclear
Concentration:	1 mg/ml
Purification Note:	From ascitic fluid Storage
Buffer:	Phosphate-buffered saline pH 7. 4 containing no preservatives
Application Note:	For WB: Use at a dilution of 1:1 000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researhcer. Target protein
Molecular Weight:	37 Myeloma: NS1 Human Replication Factor C (RFC) is a hetero-pentameric protein consisting of the p140 p40 p38 p37 and p36 subunits. RFC functions in the loading of the DNA polymerase delta processivity factor (PCNA Proliferating Cell nuclear Antigen) onto a primed DNA template during DNA synthesis and repair. RFC may also participate in the DNA damage checkpoint response with a PCNA-like hetero-trimer consisting of Hus 1 Rad 1 and Rad 9.
Function:	This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase\' s processibility during elongation of the leading strand.
Subunit:	Homotrimer. Interacts with KCTD10. Interacts with PPP1R15A (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with POLH POLK DNMT1 ERCC5/XPG FEN1 CDC6 APEX2 and POLDIP2. Interacts with EXO1 and SHPRH. Forms a ternary complex with DNTTIP2 and core histone. Interacts with POLD1 POLD3 and POLD4.
Subcellular Location:	Nucleus.
Ptm:	Upon methyl methanesulfonate-induced DNA damage mono-ubiquitinated by the UBE2B-RAD18 complex on Lys-164. This induces non-canonical poly-ubiquitination on Lys-164 through \' Lys-63\' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligase SHPRH whih is required for DNA repair.
Disease:	Antibodies are present in sera from patients with systemic lupus erythematosus.
Similarity:	Belongs to the PCNA family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 11/27/2025

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