Vergleich

CD4 [YTS 177.9] (RPE)

ArtNr 20-272-193636
Hersteller GENWAY
Menge 100 TESTS
Kategorie
Typ Antibody
Clon YTS 177. 9
Specific against other
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias GWB-2F5A14
Similar products 20-272-193636
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Genway ID:
GWB-2F5A14
Clone:
YTS 177. 9
Isotype:
IgG2a
Immunogen:
Mouse spleen cells
Antigen Species:
Mouse
Specificity:
mouse CD4
Target:
CD4
Conjugation:
RPE Storage
Buffer:
Phosphate buffered saline pH7. 2
Application Note:
Flow cytometry;
Flow Cytometry:
Use 10ul of the suggested working dilution to label 10^6 cells in 100ul. Myeloma: Spleen cells from immunised DA rats were fused with cells of the Y3/Ag1. 2. 3 rat myeloma cell line. YTS 177. 9 reacts with the Mouse CD4 antigen; non polymorphic epitope1. The antibody reacts with CD4 transfectants and blocks MHC-II dependant T-cell responses in vitro and in vivo and induces tolerance1 2.
Function:
Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Subunit:
Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with and sequesters CD4 in the endoplasmic reticulum.
Ptm:
Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Miscellaneous:
Primary receptor for HIV-1.
Similarity:
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Similarity:
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 TESTS
Lieferbar: In stock
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