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CD4 [YTS 177.9] (RPE)

CD4 [YTS 177.9] (RPE)

Item no.	20-272-193636
Manufacturer	GENWAY
Amount	100 TESTS
Category	Oncology Antibodies Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Clone	YTS 177. 9
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-2F5A14
Similar products	20-272-193636
Available
Genway ID:	GWB-2F5A14
Clone:	YTS 177. 9
Isotype:	IgG2a
Immunogen:	Mouse spleen cells
Antigen Species:	Mouse
Specificity:	mouse CD4
Target:	CD4
Conjugation:	RPE Storage
Buffer:	Phosphate buffered saline pH7. 2
Application Note:	Flow cytometry;
Flow Cytometry:	Use 10ul of the suggested working dilution to label 10^6 cells in 100ul. Myeloma: Spleen cells from immunised DA rats were fused with cells of the Y3/Ag1. 2. 3 rat myeloma cell line. YTS 177. 9 reacts with the Mouse CD4 antigen; non polymorphic epitope1. The antibody reacts with CD4 transfectants and blocks MHC-II dependant T-cell responses in vitro and in vivo and induces tolerance1 2.
Function:	Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Subunit:	Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins.
Subcellular Location:	Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with and sequesters CD4 in the endoplasmic reticulum.
Ptm:	Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Miscellaneous:	Primary receptor for HIV-1.
Similarity:	Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Similarity:	Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 TESTS

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Delivery expected until 10/30/2025

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