CD4 [W3/25] (Biotin)

ArtNr	20-272-193940
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Neuroscience Aging & Neurological Disorders Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody
Clon	W3/25
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-2E5A6A
Similar products	20-272-193940
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Genway ID:	GWB-2E5A6A
Clone:	W3/25
Isotype:	IgG1
Immunogen:	Rat thymocyte membrane
Antigen Species:	Rat
Specificity:	Rat CD4
Target:	CD4
Conjugation:	Biotin
Concentration:	0. 1 mg/ml
Purification Note:	From mouse ascitic fluid Storage
Buffer:	Phosphate buffered saline pH7. 4
Application Note:	For FACS: Use 0. 5 ug to label 10^6 cells. Protocols are available upon request. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Myeloma: Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line. Recognises the rat CD4 cell surface antigen a 55kD glycoprotein expressed by helper T cells thymocytes and macrophages.
Function:	Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Subunit:	Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins.
Subcellular Location:	Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with and sequesters CD4 in the endoplasmic reticulum.
Ptm:	Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Miscellaneous:	Primary receptor for HIV-1.
Similarity:	Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Similarity:	Contains 1 Ig-like V-type (immunoglobulin-like) domain.

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Menge: 0.1 mg

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Lieferung vsl. bis 11.09.2025

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