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CD4 [W3/25] (Biotin)

CD4 [W3/25] (Biotin)

Item no.	20-272-193940
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Neuroscience Aging & Neurological Disorders Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Clone	W3/25
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-2E5A6A
Similar products	20-272-193940
Available
Genway ID:	GWB-2E5A6A
Clone:	W3/25
Isotype:	IgG1
Immunogen:	Rat thymocyte membrane
Antigen Species:	Rat
Specificity:	Rat CD4
Target:	CD4
Conjugation:	Biotin
Concentration:	0. 1 mg/ml
Purification Note:	From mouse ascitic fluid Storage
Buffer:	Phosphate buffered saline pH7. 4
Application Note:	For FACS: Use 0. 5 ug to label 10^6 cells. Protocols are available upon request. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Myeloma: Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line. Recognises the rat CD4 cell surface antigen a 55kD glycoprotein expressed by helper T cells thymocytes and macrophages.
Function:	Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Subunit:	Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins.
Subcellular Location:	Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with and sequesters CD4 in the endoplasmic reticulum.
Ptm:	Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Miscellaneous:	Primary receptor for HIV-1.
Similarity:	Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Similarity:	Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 9/11/2025

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