PCNA

ArtNr	20-511-240241
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Antibodies Primary Antibodies By Organ Bladder Cancer
Typ	Antibody
Clon	131-11964(19
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-3E27C4
Similar products	20-511-240241
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Genway ID:	GWB-3E27C4
Isotype:	IgG1. k
Clone:	131-11964(19F4)Host Animal: Mouse
Immunogen:	Purified Proliferating Cell Nuclear Antigen
Specificity:	PCNA (Proliferating Cell Nuclear Antigen). formerly called Cyclin. is a 36 kDa proliferation associated antigen.
Type of Product:	Monoclonal Antibodies to Apoptosis and Signal Transduction Reagents
Concentration:	1. 2mg/ml (OD280nm E0. 1% = 1. 4)Preservatives: NaN3
Buffer:	10mM Phosphate pH 7. 4 containing 150mM Sodium chlorideApplications Notes : Specific methodologies have not been tested using this product.
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. MAb to PCNA. Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA)
Function:	This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase\' s processibility during elongation of the leading strand.
Subunit:	Homotrimer. Interacts with KCTD10. Interacts with PPP1R15A (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with POLH POLK DNMT1 ERCC5/XPG FEN1 CDC6 APEX2 and POLDIP2. Interacts with EXO1 and SHPRH. Forms a ternary complex with DNTTIP2 and core histone. Interacts with POLD1 POLD3 and POLD4.
Subcellular Location:	Nucleus.
Ptm:	Upon methyl methanesulfonate-induced DNA damage mono-ubiquitinated by the UBE2B-RAD18 complex on Lys-164. This induces non-canonical poly-ubiquitination on Lys-164 through \' Lys-63\' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligase SHPRH whih is required for DNA repair.
Disease:	Antibodies are present in sera from patients with systemic lupus erythematosus.
Similarity:	Belongs to the PCNA family.

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Menge: 0.1 mg

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