PCNA

Item no.	20-511-240241
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Antibodies Primary Antibodies By Organ Bladder Cancer
Type	Antibody
Clone	131-11964(19
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-3E27C4
Similar products	20-511-240241
Available
Genway ID:	GWB-3E27C4
Isotype:	IgG1. k
Clone:	131-11964(19F4)Host Animal: Mouse
Immunogen:	Purified Proliferating Cell Nuclear Antigen
Specificity:	PCNA (Proliferating Cell Nuclear Antigen). formerly called Cyclin. is a 36 kDa proliferation associated antigen.
Type of Product:	Monoclonal Antibodies to Apoptosis and Signal Transduction Reagents
Concentration:	1. 2mg/ml (OD280nm E0. 1% = 1. 4)Preservatives: NaN3
Buffer:	10mM Phosphate pH 7. 4 containing 150mM Sodium chlorideApplications Notes : Specific methodologies have not been tested using this product.
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. MAb to PCNA. Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA)
Function:	This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase\' s processibility during elongation of the leading strand.
Subunit:	Homotrimer. Interacts with KCTD10. Interacts with PPP1R15A (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with POLH POLK DNMT1 ERCC5/XPG FEN1 CDC6 APEX2 and POLDIP2. Interacts with EXO1 and SHPRH. Forms a ternary complex with DNTTIP2 and core histone. Interacts with POLD1 POLD3 and POLD4.
Subcellular Location:	Nucleus.
Ptm:	Upon methyl methanesulfonate-induced DNA damage mono-ubiquitinated by the UBE2B-RAD18 complex on Lys-164. This induces non-canonical poly-ubiquitination on Lys-164 through \' Lys-63\' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligase SHPRH whih is required for DNA repair.
Disease:	Antibodies are present in sera from patients with systemic lupus erythematosus.
Similarity:	Belongs to the PCNA family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 10/30/2025

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