Sodium/calcium exchanger 1

Fusion protein from the N-terminus of rabbit renal Na/Ca ExchangerWorking

6H2

Specific for the ~120k and [160k] Na+/Ca2+ Exchanger NaCX-1 protein in Western blots of rabbit tissues. Has broad tissue and species reactivity. Quality Control Tests: Western blots performed on each lotPackaging: 100 Â µ g antibody vial; lyophilized from 5mM ammonium bicarbonate. Adequate amount of material to conduct 10-mini Western blots

By ATP.

Cardiac sarcolemma or brain and spleen. Isoform 4 seems to be a predominant isoform in aorta stomach liver and kidney.

Contains 2 Calx-beta domains. [1] Ahlers B. A. Zhang X. Q. Moorman J. R. Rothblum L. I. Carl L. L. Song J. Wang J. Geddis L. M. Tucker A. L. Mounsey J. P. and et al. Identification of an endogenous inhibitor of the cardiac Na+/Ca2+ exchanger phospholemman[2] Egger M. Porzig H. Niggli E. and Schwaller B. et al. Rapid turnover of the \' functional\' Na(+)-Ca2+ exchanger in cardiac myocytes revealed by an antisense oligodeoxynucleotide approach[3] Pignataro G. Gala R. Cuomo O. Tortiglione A. Giaccio L. Castaldo P. Sirabella R. Matrone C. Canitano A. Amoroso S. Di et al. Two sodium/calcium exchanger gene products NCX1 and NCX3 play a major role in the development of permanent focal cerebral ischemia[4] Cha S. H. Shin S. Y. Jung S. Y. Kim Y. T. Park Y. J. Kwak J. O. Kim H. W. and Suh C. K. Evidence for Na+/Ca2+ exchanger 1 association with caveolin-1 and -2 in C6 glioma cells[5] Nagano T. Kawasaki Y. Baba A. Takemura M. and Matsuda T. et al. Up-regulation of Na(+)-Ca2+ exchange activity by interferon-gamma in cultured rat microglia[6] Low W. Kasir J. Rahamimoff H. Cloning of the rat heart Na(+)-Ca2+ exchanger and its functional expression in HeLa cells. [7] Furman I. Cook O. Kasir J. Rahamimoff H. Cloning of two isoforms of the rat brain Na(+)-Ca2+ exchanger gene and their functional expression in HeLa cells. [8] Nakasaki Y. Iwamoto T. Hanada H. Imagawa T. Shigekawa M. Cloning of the rat aortic smooth muscle Na+/Ca2+ exchanger and tissue-specific expression of isoforms. [9] Lee S. -L. Yu A. S. L. Lytton J. Tissue-specific expression of Na(+)-Ca2+ exchanger isoforms. [10] Nicoll D. A. Quednau B. D. Qui Z. Xia Y. -R. Lusis A. J. Philipson K. D. Cloning of a third mammalian Na+-Ca2+ exchanger NCX3.