Hersteller |
GENWAY
|
Kategorie |
|
Typ |
Antibody |
Specific against |
other |
Clon |
AT13/5 |
Applikationen |
FC |
Menge |
0.025 mg |
ArtNr |
20-783-310008 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Genway ID: |
GWB-64B71B |
Specificity: |
CD38NCBI |
Gene ID: |
952 |
Specificity: |
CD38 |
Clone: |
AT13/5 |
Fusion Partner: |
Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line. |
Specificity Note: |
This product recognises the human CD38 cell surface antigen a 45kD glycoprotein. CD38 is expressed by plasma cells monocytes early lymphoid cells and activated T cells. CD38 is widely used to study the processes of T and B cell differentiation and activation. Recently CD38 has been shown to possess ADP-ribosyl cyclase activity. |
Preparation: |
Purified IgG prepared by affinity chromatography on Protein A |
Buffer Solution: |
Phosphate buffered saline pH7. 4 |
|
Preservative Stabilisers: |
| 0. 09%Sodium Azide1%Bovine Serum AlbuminSuggested |
Flow Cytometry: |
Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood. Suggested |
Dilution: |
Flow Cytometry - Neat |
Function: |
Synthesizes cyclic ADP-ribose a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. |
Catalytic Activity: |
NAD+ + H2O = ADP-ribose + nicotinamide. |
Enzyme Regulation: |
ATP inhibits the hydrolyzing activity. |
Subcellular Location: |
Membrane; Single-pass type II membrane protein. |
Tissue Specificity: |
Expressed at high levels in pancreas liver kidney brain testis ovary placenta malignant lymphoma and neuroblastoma. Developmental Stage: Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E. |
Similarity: |
Belongs to the ADP-ribosyl cyclase family. 1. Malavasi. F. et al. (1994) Human CD38: a glycoprotein in search of a function. 2. Ellis. J. H. et al. (1995) Engineered anti-CD38 monoclonal antibodies for immunotherapy of multiple myeloma. |
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