CD38


Manufacturer	GENWAY
Category	Oncology Antibodies Flow Cytometry Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Specific against	other
Clone	AT13/5
Applications	FC
Amount	0.025 mg
Item no.	20-783-310008
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-64B71B
Specificity:	CD38NCBI
Gene ID:	952
Specificity:	CD38
Clone:	AT13/5
Fusion Partner:	Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
Specificity Note:	This product recognises the human CD38 cell surface antigen a 45kD glycoprotein. CD38 is expressed by plasma cells monocytes early lymphoid cells and activated T cells. CD38 is widely used to study the processes of T and B cell differentiation and activation. Recently CD38 has been shown to possess ADP-ribosyl cyclase activity.
Preparation:	Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium Azide1%Bovine Serum AlbuminSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood. Suggested
Dilution:	Flow Cytometry - Neat
Function:	Synthesizes cyclic ADP-ribose a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
Catalytic Activity:	NAD+ + H2O = ADP-ribose + nicotinamide.
Enzyme Regulation:	ATP inhibits the hydrolyzing activity.
Subcellular Location:	Membrane; Single-pass type II membrane protein.
Tissue Specificity:	Expressed at high levels in pancreas liver kidney brain testis ovary placenta malignant lymphoma and neuroblastoma. Developmental Stage: Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.
Similarity:	Belongs to the ADP-ribosyl cyclase family. 1. Malavasi. F. et al. (1994) Human CD38: a glycoprotein in search of a function. 2. Ellis. J. H. et al. (1995) Engineered anti-CD38 monoclonal antibodies for immunotherapy of multiple myeloma.

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Amount: 0.025 mg

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Delivery expected until 5/30/2024