CD4

GWB-9F83FB

920

RPA-T4

Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.

Phosphate buffered saline pH7. 4

Use 10ul of the suggested working dilution to label 106 cells or 100ul whole bloodSuggested

Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.

Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with and sequesters CD4 in the endoplasmic reticulum.

Primary receptor for HIV-1.

Contains 1 Ig-like V-type (immunoglobulin-like) domain. 1. Zarkesh-Esfahani. H. et al. (2001) High-dose leptin activates human leukocytes via receptor expression on monocytes. 2. Voehringer. D. et al. (2002) Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectin-like receptor G1 (KLRG1). 3. Piatier-Tonneau. D. (1997) CD4 workshop panel report. In Leucocyte Typing VI. White cell differentiation antigens. Edited by Kishimoto. T. . Kikutani. H. . von dem Borne. A. E. G. Kr. . Goyert. A. M. . Mason. D. Y. . Miyasaka. M. . Moretta. L. . Okumura. K. . Shaw. S. . Springer. T. A. . Sugamura. K. . Zola. H. Garland publishing Inc. New York & London.