CD4

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone RPA-T4
Applications FC
Amount 25 TESTS
ArtNr 20-783-310044
Available
Genway ID:
GWB-9F83FB
Specificity:
CD4NCBI
Gene ID:
920
Specificity:
CD4
Clone:
RPA-T4
Immunogen:
Human PHA blasts
Fusion Partner:
Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium Azide1%Bovine Serum Albumin
Reconstitution: Reconstitute in 0. 25 ml disilled waterSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells or 100ul whole bloodSuggested
Dilution:
Flow Cytometry - Neat
Function:
Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Subunit:
Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with and sequesters CD4 in the endoplasmic reticulum.
Ptm:
Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Miscellaneous:
Primary receptor for HIV-1.
Similarity:
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Similarity:
Contains 1 Ig-like V-type (immunoglobulin-like) domain. 1. Zarkesh-Esfahani. H. et al. (2001) High-dose leptin activates human leukocytes via receptor expression on monocytes. 2. Voehringer. D. et al. (2002) Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectin-like receptor G1 (KLRG1). 3. Piatier-Tonneau. D. (1997) CD4 workshop panel report. In Leucocyte Typing VI. White cell differentiation antigens. Edited by Kishimoto. T. . Kikutani. H. . von dem Borne. A. E. G. Kr. . Goyert. A. M. . Mason. D. Y. . Miyasaka. M. . Moretta. L. . Okumura. K. . Shaw. S. . Springer. T. A. . Sugamura. K. . Zola. H. Garland publishing Inc. New York & London.
Amount: 25 TESTS
Available: In stock
Listprice: €283.64
Discount: -10.0%
Price: €255.28
You save: €28.36
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