CD11a


Hersteller	GENWAY
Kategorie	Oncology Antibodies Flow Cytometry Primary Antibodies By Organ Skin Cancer
Typ	Antibody
Specific against	other
Clon	I21/7
Applikationen	FC
Menge	25 TESTS
ArtNr	20-783-310066
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Genway ID:	GWB-CC78DE
Specificity:	CD11aNCBI
Gene ID:	16408
Specificity:	CD11a
Clone:	I21/7
Immunogen:	Whole BW5147 cells
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium Azide1%Bovine Serum Albumin Reconstitution: Reconstitute in 0. 25 ml disilled waterSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested
Dilution:	Flow Cytometry - Neat - 1/2
Function:	Integrin alpha-L/beta-2 is a receptor for ICAM1 ICAM2 ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction cytotoxic T-cell mediated killing and antibody dependent killing by granulocytes and monocytes.
Subunit:	Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	Leukocytes.
Domain:	The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Similarity:	Belongs to the integrin alpha chain family.
Similarity:	Contains 7 FG-GAP repeats.
Similarity:	Contains 1 VWFA domain. 1. Trowbridge. I. S. and Omary. M. B. (1981) Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen MAC-1. 2. Champe. M. et al. (1995) Monoclonal Antibodies That Block the Activity of Leukocyte Function-associated Antigen-1 Recognize Three Discrete Epitopes in the Inserted Domain of CD11a. 3. Springer. T. et al. (1982) LFA-1 and Lyt-2. 3. molecules associated with T lymphocyte-mediated killing; and Mac-1. an LFA-1 homologue associated with complement receptor function 4. Falanga. P. B. and Butcher E. C. (1991) Late treatment with anti-LFA-1 (CD11a) antibody prevents cerebral malaria in a mouse model. 5. Campbell. S. B. et al. (2001) CD4 ligation promotes the IL-4-independent development of IL-4-producing clones from naive CD4(+) T cells 6. Talento. A. et al. (1993) A single administration of LFA-1 antibody confers prolonged allograft survival. 7. Barret. T. B. et al. (1991) CD40 signaling activates CD11a/CD18 (LFA-1)-mediated adhesion in B cells.

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

Produkdatenblatt anfordern

Sicherheitsdatenblatt anfordern

Einfache Bestellung Periodische Bestellung

Menge: 25 TESTS

lieferbar

Lieferung vsl. bis 30.05.2024

Vergleichen

Auf den Wunschzettel

Weiterempfehlen per Mail

Angebot anfordern