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G-CSF RECEPTOR

G-CSF RECEPTOR


Hersteller	GENWAY
Kategorie	Oncology Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Adenocarcinoma Mesothelioma Flow Cytometry Primary Antibodies By Organ Bone Cancer
Typ	Antibody
Specific against	other
Clon	LMM775
Applikationen	FC
Menge	25 TESTS
ArtNr	20-783-310109
eClass 6.1	32160702
eClass 9.0	32160702
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Genway ID:	GWB-49C305
Specificity:	G-CSF RECEPTORNCBI
Gene ID:	1441
Specificity:	G-CSF RECEPTOR
Clone:	LMM775
Preparation:	Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium Azide1%Bovine Serum Albumin Reconstitution: Reconstitute in 0. 25 ml disilled waterSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood. Suggested
Dilution:	Flow Cytometry - Neat
Function:	Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface.
Subunit:	Homodimer. The dimeric receptor binds two CSF3 molecules.
Subcellular Location:	Isoform 2: Secreted (Probable).
Subcellular Location:	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity:	One or several isoforms have been found in myelogenous leukemia cell line KG-1 leukemia U937 cell line in bone marrow cells placenta and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U937 cells. Isoform GSCFR-3 is highly expressed in placenta.
Domain:	The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
Domain:	The box 1 motif is required for JAK interaction and/or activation.
Disease:	Defects in CSF3R may be a cause of severe congenital neutropenia (SCN) in some patients.
Similarity:	Belongs to the type I cytokine receptor family. Type 2 subfamily.
Similarity:	Contains 5 fibronectin type-III domains.
Similarity:	Contains 1 Ig-like C2-type (immunoglobulin-like) domain. 1. Nicholson. S. E. et al. (1994) Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation.

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Menge: 25 TESTS

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Lieferung vsl. bis 30.05.2024

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