CD340


Hersteller	GENWAY
Kategorie	Oncology Neuroscience Neural Adhesion Molecules Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Immunohistochemistry Immunoprecipitation Western Blot Primary Antibodies By Organ Lung Cancer Bladder Cancer Colorectal Cancer Breast Cancer
Typ	Antibody
Specific against	other
Clon	ICR55
Applikationen	WB, IP, IHC
Menge	0.025 mg
ArtNr	20-783-310158
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Genway ID:	GWB-AED1BC
Specificity:	CD340NCBI
Gene ID:	2064
Specificity:	CD340
Clone:	ICR55
Preparation:	Purified IgG prepared by ion exchange chromatography from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		0. 02%Sodium Azide
Function:	Essential component of a neuregulin-receptor complex although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF TGF-alpha and amphiregulin.
Catalytic Activity:	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit:	Heterodimer with each of the other ERBB receptors (Potential). Interacts with PRKCABP and PLXNB1. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with MEMO when phosphorylated on Tyr-1248. Interacts with MUC1. Stimulation by heregulin (HRG) in breast cancer cell lines induces binding of MUC1 with gamma-catenin.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Ptm:	Ligand-binding increases phosphorylation on tyrosine residues (By similarity).
Polymorphism:	There are fours alleles due to the variations in positions 654 and 655. Allele B1 (Ile-654/Ile-655) has a frequency of 0. 782; allele B2 (Ile-654/Val-655) has a frequency of 0. 206; allele B3 (Val-654/Val-655) has a frequency of 0. 012.
Similarity:	Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Similarity:	Contains 1 protein kinase domain. 1. Styles. J. M. et al. (1990) Rat monoclonal antibodies to the external domain of the product of the c-erbB-2 proto-oncogene. 2. Dean. C. J. et al. (1993) Rat MAbs to the product of the c-erbB-2 proto-oncogene for diagnosis and therapy in breast cancer.

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Menge: 0.025 mg

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