CD161

GWB-BD520A

MCA1855 recognises the hyman CD161 cell surface antigen expressed by almost all NK cells and with a small subset of CD3+ve T cells. CD161 is a homodimeric cell surface protein comprising two chains of 40-44kD. Clone B199. 2 recognises a similar epitope to the DX9 monoclonal antibody.

3820

B199. 2

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1 3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.

Membrane; Single-pass type II membrane protein (Potential).

By IL12 in NK cells.

Contains 1 C-type lectin domain. 1. Bennett. I. M. et al. (1996) Definition of natural killer NKR-PIA+/CD56-/CD16- functionally immature human NK cell subset that differentiates in vitro in the presence of interleukin 12. 2. Azzoni. L. et al. (1998) Differential transcriptional regulation of CD161 and a novel gene. 197/15a. by IL-2. IL-15. and IL-12 in NK and T cells.