CD49d


Hersteller	GENWAY
Kategorie	Oncology Neuroscience Neural Adhesion Molecules Antibodies Cell Biology Cell Movement Cell Adhesion Flow Cytometry Immunohistochemistry Immunoprecipitation Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody
Specific against	other
Clon	R1-2
Applikationen	FC, IP, IHC
Menge	0.025 mg
ArtNr	20-783-310240
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Genway ID:	GWB-32C014
Specificity:	CD49dNCBI
Gene ID:	16401
Specificity:	CD49d
Clone:	R1-2
Immunogen:	Lymphoma cell line TK1
Fusion Partner:	Spleen cells from immunised Fisher rats were fused with cells of the P3x63Ag8. 653 mouse myeloma cell line.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		0. 09%Sodium AzideSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Function:	Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
Subunit:	Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN LPXN and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Domain:	The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.
Ptm:	Phosphorylation on Ser-1027 inhibits PXN binding.
Similarity:	Belongs to the integrin alpha chain family.
Similarity:	Contains 7 FG-GAP repeats. 1. Kamata. K et al. (1995) Identification of putative ligand-binding sites of the integrin alpha4/beta1 (VLA-4. CD49d/CD29). 2. Holzmann. B. et al. (1989) Integrin molecules involved in lymphocyte homing to Peyer\' s patches.

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Menge: 0.025 mg

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Lieferung vsl. bis 30.05.2024

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