CD49d


Manufacturer	GENWAY
Category	Oncology Neuroscience Neural Adhesion Molecules Antibodies Cell Biology Cell Movement Cell Adhesion Flow Cytometry Immunohistochemistry Immunoprecipitation Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Specific against	other
Clone	R1-2
Applications	FC, IP, IHC
Amount	0.025 mg
Item no.	20-783-310240
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-32C014
Specificity:	CD49dNCBI
Gene ID:	16401
Specificity:	CD49d
Clone:	R1-2
Immunogen:	Lymphoma cell line TK1
Fusion Partner:	Spleen cells from immunised Fisher rats were fused with cells of the P3x63Ag8. 653 mouse myeloma cell line.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		0. 09%Sodium AzideSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Function:	Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
Subunit:	Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN LPXN and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Domain:	The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.
Ptm:	Phosphorylation on Ser-1027 inhibits PXN binding.
Similarity:	Belongs to the integrin alpha chain family.
Similarity:	Contains 7 FG-GAP repeats. 1. Kamata. K et al. (1995) Identification of putative ligand-binding sites of the integrin alpha4/beta1 (VLA-4. CD49d/CD29). 2. Holzmann. B. et al. (1989) Integrin molecules involved in lymphocyte homing to Peyer\' s patches.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 0.025 mg

available

Delivery expected until 5/30/2024