CD49d

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone R1-2
Applications FC, IP, IHC
Amount 0.025 mg
ArtNr 20-783-310240
Available
Genway ID:
GWB-32C014
Specificity:
CD49dNCBI
Gene ID:
16401
Specificity:
CD49d
Clone:
R1-2
Immunogen:
Lymphoma cell line TK1
Fusion Partner:
Spleen cells from immunised Fisher rats were fused with cells of the P3x63Ag8. 653 mouse myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G
Buffer Solution:
Phosphate buffered saline
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Function:
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
Subunit:
Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN LPXN and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Domain:
The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.
Ptm:
Phosphorylation on Ser-1027 inhibits PXN binding.
Similarity:
Belongs to the integrin alpha chain family.
Similarity:
Contains 7 FG-GAP repeats. 1. Kamata. K et al. (1995) Identification of putative ligand-binding sites of the integrin alpha4/beta1 (VLA-4. CD49d/CD29). 2. Holzmann. B. et al. (1989) Integrin molecules involved in lymphocyte homing to Peyer\' s patches.
Amount: 0.025 mg
Available: In stock
Listprice: €152.38
Discount: -10.0%
Price: €137.14
You save: €15.24
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