Hersteller |
GENWAY
|
Kategorie |
|
Typ |
Antibody |
Specific against |
other |
Clon |
DX5 |
Applikationen |
FC |
Menge |
0.025 mg |
ArtNr |
20-783-310248 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Genway ID: |
GWB-522DA0 |
Specificity: |
CD49bNCBI |
Gene ID: |
16398 |
Specificity: |
CD49b |
Clone: |
DX5 |
Immunogen: |
RIL-2 propogated NK1. 1+ cells from C57BL/6 mice. |
Fusion Partner: |
Mouse SP2/0 myeloma line. |
Buffer Solution: |
Borate buffered saline pH8. 0 |
|
Preservative Stabilisers: |
| 0. 09%Sodium AzideSuggested |
Flow Cytometry: |
Use 10ul of the suggested working dilution to label 106 cells in 100ul. |
Function: |
Integrin alpha-2/beta-1 is a receptor for laminin collagen collagen C-propeptides fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens modulation of collagen and collagenase gene expression force generation and organization of newly synthesized extracellular matrix. |
Subunit: |
Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. |
Subcellular Location: |
Membrane; Single-pass type I membrane protein. |
Domain: |
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. |
Polymorphism: |
Position 534 is associated with platelet-specific alloantigen HPA-5 (Br). HPA-5A/Br(a) has Lys-534 and HPA-5B/Br(b) has Glu-534. HPA-5B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP). The Lys-534-Glu polymorphism may play a role in coronary artery disease (CAD). |
Similarity: |
Belongs to the integrin alpha chain family. |
Similarity: |
Contains 7 FG-GAP repeats. |
Similarity: |
Contains 1 VWFA domain. 1. Arase. H. et al. (2001) Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin. very late antigen-2) |
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