Hersteller |
GENWAY
|
Kategorie |
|
Typ |
Antibody |
Specific against |
other |
Clon |
MR5D3 |
Applikationen |
FC |
Menge |
0.025 mg |
ArtNr |
20-783-310286 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Genway ID: |
GWB-72469F |
Specificity: |
CD206NCBI |
Gene ID: |
17533 |
Specificity: |
CD206 |
Clone: |
MR5D3 |
Immunogen: |
Chimaeric CRD4-7-Fc protein. |
Fusion Partner: |
Spleen cells from immunised Fischer rats were fused with cells of the Y3 myeloma cell line. |
Preparation: |
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant |
Buffer Solution: |
Phosphate buffered saline pH7. 4 |
|
Preservative Stabilisers: |
| 0. 09%Sodium Azide1%Bovine Serum AlbuminSuggested |
Flow Cytometry: |
Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested |
Dilution: |
Flow Cytometry - Neat - 1/10 |
Function: |
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria fungi and other pathogens. |
Subcellular Location: |
Membrane; Single-pass type I membrane protein. |
Miscellaneous: |
CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4 5 and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates. |
Similarity: |
Contains 8 C-type lectin domains. |
Similarity: |
Contains 1 fibronectin type-II domain. |
Similarity: |
Contains 1 ricin B-type lectin domain. 1. Martinez-Pomares. L. et al. (2003) Analysis of mannose receptor regulation by IL-4. IL-10 and proteolytic processing using novel monoclonal antibodies. 2. Zamze. S. et al. (2002) Recognition of bacterial capsular polysaccharides and lipopolysaccharides by the macrophage mannose receptor. |
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