CD127

CD127NCBI

CD127

Pre-B cell line 1A9

Phosphate buffered saline pH7. 4

Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested

Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

Isoform H20: Cell membrane; Single-pass type I membrane protein.

Isoform H6: Secreted.

The box 1 motif is required for JAK interaction and/or activation.

A genetic variation in transmembrane domain of IL7R is associated with susceptibility to multiple sclerosis (MS) [MIM:126200]. Overtransmission of the major \' C\' allele coding for Thr-244 are detected in offspring affected with multiple sclerosis. In vitro analysis of transcripts from minigenes containing either \' C\' allele (Thr-244) or \' T\' allele (Ile-244) shows that the \' C\' allele results in an approximately two-fold increase in the skipping of exon 6 leading to increased production of a soluble form of IL7R. Thus the multiple sclerosis associated \' C\' risk allele of IL7R would probably decrease membrane-bound expression of IL7R. As this risk allele is common in the general population some additional triggers are probably required for the development and progression of MS.

Contains 1 fibronectin type-III domain. 1. Kouro. T. et al. (2002) Relationship between early B-and NK-lineage lymphocyte precursors in bone marrow. 2. Yamashita. Y. et al. (1999) Syndecan-4 is expressed by B lineage lymphocytes and can transmit a signal for formation of dendritic processes.